BACKGROUND:Tissue inhibitor of metalloproteinases-1 (TIMP-1) displays pleiotropic activities. both dependent and independent of its inhibitory activity on matrix metalloproteinases (MMPs). In the central nervous system (CNS). TIMP-1 is strongly upregulated in reactive astrocytes and cortical neurons following excitotoxic/inflammatory stimuli. https://emporiumsmokeshopstles.shop/product-category/nails/