Abstract Background Molecular mechanisms involved in the pathogenesis of severe Plasmodium falciparum malaria (SM). are not yet fully understood. Both endothelin-1 (ET-1) and C-type natriuretic peptide (CNP) are produced by vascular endothelium and act locally as paracrine regulators of vascular tone. ET-1 being a potent vasoconstrictor and CNP having strong vasorelaxant properties. https://www.roneverhart.com/Brach-s-Natural-Sources-Candy-Corn-10-Ounce-Bag/